Muscle Physiology and Contraction · USMLE Step 1

Which structure is the basic contractile unit of skeletal muscle that shortens during contraction?

  1. Motor unit
  2. Myofibril
  3. Sarcomere
  4. Myofilament
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Correct answer: Sarcomere

The sarcomere — the segment between two Z-discs — is the functional unit that shortens when muscle contracts, as thin (actin) and thick (myosin) filaments slide past each other.

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