Muscle Physiology and Contraction · USMLE Step 1

Which process describes the repeated attachment, pivoting (power stroke), detachment, and re-cocking of myosin heads during muscle contraction?

  1. Calcium cycling
  2. Cross-bridge cycle
  3. Sliding filament shift
  4. Excitation–contraction coupling
Show answer and explanation

Correct answer: Cross-bridge cycle

The cross-bridge cycle is the molecular mechanism of contraction — myosin heads cyclically bind to actin, undergo a power stroke using ATP, detach, and re-attach, driving filament sliding.

Difficulty: Medium Question 6 of 20

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