Endocrine regulation · USMLE Step 1

Which situation would likely lead to increased (GH) secretion from the anterior pituitary?

  1. High somatostatin release from hypothalamus
  2. Sustained high blood glucose levels
  3. Ghrelin release during fasting
  4. High circulating IGF-1 concentrations
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Correct answer: Ghrelin release during fasting

Ghrelin, released during fasting, stimulates growth hormone (GH) secretion. In contrast, high somatostatin, sustained high blood glucose, and high circulating IGF-1 all inhibit GH release through inhibitory hormones or negative feedback.

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