In chronic kidney disease due to long-term vascular or glomerular injury, what histopathologic mechanism underlies progressive loss of nephron function?
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Correct answer: Interstitial fibrosis with glomerulosclerosis and tubular atrophy
Repeated injury leads to glomerulosclerosis, tubular atrophy, and interstitial fibrosis, replacing functional nephrons with scar tissue and causing progressive renal failure.
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