Renal and Urinary: Glomerulonephritis, AKI · USMLE Step 1

A 25-year-old man with hematuria and anemia has sickle cell disease. Which renal condition is most likely?

  1. Renal papillary necrosis
  2. Minimal change disease
  3. Membranous nephropathy
  4. RPGN
Show answer and explanation

Correct answer: Renal papillary necrosis

Sickle cell disease causes ischemia of renal papillae leading to papillary necrosis, presenting with hematuria and flank pain.

Difficulty: Medium Question 18 of 20

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