Host immune response · USMLE Step 1

Natural killer (NK) cells primarily kill which type of cells?

  1. Cells expressing high MHC I
  2. Cells lacking MHC I
  3. Neutrophils
  4. Mast cells
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Correct answer: Cells lacking MHC I

NK cells target cells with reduced or absent MHC I expression, typical of virus-infected or tumor cells.

Difficulty: Medium Question 7 of 20

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