Bacteria: Structure and Pathogenesis · USMLE Step 1

Which structural feature allows Gram-positive bacteria to survive harsh environmental conditions without an outer membrane?

  1. Protective lipopolysaccharide outer layer
  2. Thick peptidoglycan with teichoic acids
  3. Periplasmic space with degrading enzymes
  4. Selective outer membrane porins
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Correct answer: Thick peptidoglycan with teichoic acids

Gram-positive bacteria rely on a thick, cross-linked peptidoglycan wall along with teichoic and lipoteichoic acids to confer structural stability and protection.

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