Cell cycle and apoptosis · USMLE Step 1

Which of the following describes a reason why the cell cycle is tightly regulated with checkpoints rather than proceeding continuously?

  1. To accelerate tissue growth as quickly as biologically possible
  2. To permit uncontrolled proliferation in response to injury
  3. To verify DNA is accurately replicated and errors repaired before division
  4. To force immediate entry into mitosis right after cytokinesis
Show answer and explanation

Correct answer: To verify DNA is accurately replicated and errors repaired before division

Checkpoints monitor for DNA damage, proper replication, and accurate chromosome attachment to the spindle, thereby preventing propagation of genetic errors to daughter cells and maintaining genomic integrity.

Difficulty: Medium Question 13 of 19

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