Embryologic Development and Defects · USMLE Step 1

A neonate has a systolic murmur and imaging reveals failure of the aorticopulmonary septum to develop properly. Which congenital defect is likely present?

  1. Tetralogy of Fallot
  2. Persistent truncus arteriosus
  3. Transposition of the great arteries
  4. Coarctation of the aorta
Show answer and explanation

Correct answer: Persistent truncus arteriosus

Persistent truncus arteriosus results from failure of neural crest-derived conotruncal ridges to fuse. This forms a single outflow tract.

Difficulty: Medium Question 8 of 20

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