Transcription and Translation · USMLE Step 1

During eukaryotic transcription initiation, which component directly binds the TATA box in the promoter region to help recruit RNA polymerase II?

  1. TFIID (TATA-binding protein)
  2. Sigma factor
  3. EF-Tu
  4. Spliceosome
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Correct answer: TFIID (TATA-binding protein)

In eukaryotic transcription initiation, the general transcription factor TFIID — containing TATA-binding protein (TBP) — binds the TATA box and helps recruit RNA polymerase II to form the pre-initiation complex.

Difficulty: Medium Question 12 of 22

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