Membrane Transport Mechanisms · Physiology

Which of the following statements best explains why facilitated diffusion exhibits a maximum transport rate (Vmax) whereas simple diffusion does not?

  1. Facilitated diffusion uses ATP that runs out at high substrate concentration
  2. Simple diffusion requires binding to membrane carrier proteins that saturate
  3. Facilitated diffusion uses a finite number of carriers that saturate when fully occupied
  4. Simple diffusion occurs only for dissolved gases and therefore cannot saturate
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Correct answer: Facilitated diffusion uses a finite number of carriers that saturate when fully occupied

Facilitated diffusion depends on carrier proteins; because there are a limited number of such transporters, once they are all occupied the transport rate cannot increase further, resulting in saturation (Vmax). Simple diffusion through the lipid bilayer does not have this limitation.

Difficulty: Medium Question 18 of 24

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