Motility and peristalsis · Physiology

Which of the following neurotransmitters is the primary excitatory mediator of circular muscle contraction behind a food bolus?

  1. Nitric Oxide
  2. Acetylcholine
  3. Vasoactive Intestinal Peptide (VIP)
  4. Dopamine
Show answer and explanation

Correct answer: Acetylcholine

Acetylcholine (along with Substance P) is the major excitatory neurotransmitter released by the myenteric plexus. It binds to muscarinic receptors on smooth muscle to cause the contraction that propels the bolus forward.

Difficulty: Medium Question 40 of 40

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