A patient is found to have a lack of ganglionic cells in the myenteric plexus of the distal colon. What is the most likely clinical manifestation?
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Correct answer: Severe constipation and megacolon
This describes Hirschsprung's disease, where the absence of the enteric nervous system (myenteric plexus) prevents peristalsis in the affected segment. This results in a functional obstruction, causing fecal buildup and massive dilation of the proximal colon.
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