Trypsin is a highly 'dangerous' enzyme if activated prematurely. Which mechanism protects the pancreas from accidental autodigestion by trypsin?
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Correct answer: The presence of Pancreatic Secretory Trypsin Inhibitor (PSTI)
The pancreas produces PSTI (also called SPINK1), which binds to and inactivates any trypsin that is accidentally activated within the gland. This prevents a premature cascade of protease activation that would lead to pancreatitis.
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