Bile salts are essential for fat digestion, but they can actually inhibit the action of pancreatic lipase by displacing it from the fat droplet. How does the body overcome this?
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Correct answer: By secreting colipase, which anchors lipase to the droplet
Colipase is a small protein secreted by the pancreas in an inactive form (procolipase) and activated by trypsin. It binds to both the bile-salt-coated lipid droplet and pancreatic lipase, acting as a bridge that allows lipase to access the underlying triglycerides.
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