Pituitary and Thyroid Physiology · Physiology

By what mechanism do hypothalamic releasing hormones, such as TRH, reach the anterior pituitary gland?

  1. Retrograde axonal transport through the infundibulum
  2. Diffusion through the cerebrospinal fluid of the third ventricle
  3. The hypothalamic-hypophyseal portal venous system
  4. Direct neural stimulation of the pars distalis
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Correct answer: The hypothalamic-hypophyseal portal venous system

Hypothalamic hormones are secreted into the primary capillary plexus of the median eminence. They travel through the portal veins to the anterior pituitary, allowing for high local concentrations without systemic dilution.

Difficulty: Medium Question 21 of 40

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