Menstrual Cycle and Spermatogenesis · Physiology

What happens to the level of GnRH secretion when testosterone levels in the blood become excessively high?

  1. GnRH secretion rises to compensate
  2. GnRH secretion decreases due to negative feedback
  3. GnRH secretion stays constant while LH selectively falls
  4. GnRH secretion is permanently and irreversibly halted
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Correct answer: GnRH secretion decreases due to negative feedback

Testosterone exerts negative feedback on both the hypothalamus (decreasing GnRH pulse frequency) and the anterior pituitary (decreasing LH/FSH sensitivity). This maintains homeostatic levels of androgens.

Difficulty: Medium Question 40 of 40

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