Which of the following intracellular changes occurs immediately after a Beta-2 agonist binds to its receptor on bronchial smooth muscle?
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Correct answer: Activation of Gs protein and increase in cAMP
Beta-2 agonists are Gs-protein-coupled receptor agonists. Binding stimulates adenylyl cyclase to convert ATP into cyclic AMP (cAMP), which then activates protein kinase A to induce muscle relaxation.
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