Which of the following is a potential serious side effect of Natalizumab, used in the treatment of Multiple Sclerosis?
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Correct answer: Progressive Multifocal Leukoencephalopathy (PML)
Natalizumab blocks alpha-4 integrin, preventing lymphocytes from crossing the blood-brain barrier. However, this local immunosuppression can allow the JC virus to reactivate in the brain, leading to the potentially fatal infection PML.
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