Which agent is used as an 'antidote' to reverse the effects of the anticoagulant Dabigatran?
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Correct answer: Idarucizumab
Idarucizumab is a humanised monoclonal antibody fragment (Fab) that binds dabigatran with an affinity roughly 350 times that of thrombin, giving immediate and complete reversal of its anticoagulant effect. Andexanet alfa is the reversal agent for the factor Xa inhibitors such as apixaban and rivaroxaban, not for dabigatran. Eculizumab is used in paroxysmal nocturnal haemoglobinuria and palivizumab in RSV prophylaxis.
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