Which antibody class is primarily responsible for ABO incompatibility reactions?
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Correct answer: IgM
ABO antibodies are predominantly IgM. IgM activates complement efficiently, leading to intravascular hemolysis. This explains the rapid and severe nature of ABO mismatch reactions.
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More Blood Transfusion Reactions questions
- Which transfusion reaction may lead to disseminated intravascular coagulation (DIC)?
- Which preventive strategy reduces the risk of graft-versus-host disease in transfusion recipients?
- Which delayed complication of transfusion is associated with anti-Rh antibodies?
- Which sign suggests hemolysis during transfusion?
- Which of the following is the most common type of acute transfusion reaction?
- An acute hemolytic transfusion reaction is most commonly caused by: