Antiplatelet Drugs · Pharmacology

Platelet activation involves the release of granules containing which substances that further amplify aggregation?

  1. ADP and Serotonin (5-HT)
  2. Insulin and Glucagon
  3. Acetylcholine (ACh) and Dopamine
  4. Heparin and Histamine
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Correct answer: ADP and Serotonin (5-HT)

Upon activation, platelets undergo degranulation, releasing ADP from dense granules and various proteins from alpha-granules. ADP then binds to P2Y1 and P2Y12 receptors on nearby platelets to recruit them into the growing clot.

Difficulty: Medium Question 18 of 20

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