What occurs during the process of receptor 'Down-regulation'?
Show answer and explanation
Correct answer: The number of surface receptors decreases after chronic agonist exposure
Continuous stimulation of receptors by agonists often leads to their internalization and degradation. This decrease in receptor density is a key mechanism behind the development of pharmacodynamic tolerance.
Keep practicing
More Pharmacodynamics questions
- Which of the following is an example of 'Functional Antagonism'?
- A 'Spare Receptor' population exists when:
- The binding of a drug to a receptor is typically governed by which type of chemical bond to ensure reversibility?
- Which statement best describes 'Tachyphylaxis'?
- The 'Intrinsic Activity' of a competitive antagonist is:
- Which of the following receptor types functions by translocating to the nucleus to regulate gene transcription?