Pharmacodynamics · Pharmacology

The binding of a drug to a receptor is typically governed by which type of chemical bond to ensure reversibility?

  1. Strong covalent bonds formed with residues in the receptor active site
  2. Weak non-covalent forces such as hydrogen and Van der Waals bonds
  3. Disulfide bridges linking the drug to cysteine residues
  4. Permanent peptide bonds with the receptor protein backbone
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Correct answer: Weak non-covalent forces such as hydrogen and Van der Waals bonds

Most drug-receptor interactions are reversible and rely on weak forces like electrostatic, hydrogen, and Van der Waals bonds. Covalent bonds are much stronger and usually result in irreversible binding.

Difficulty: Medium Question 12 of 20

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