How does 'Enzyme Induction' affect the metabolism of a co-administered drug that is a substrate for the same enzyme?
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Correct answer: It increases the rate of metabolism, potentially leading to therapeutic failure
Enzyme inducers (like Rifampin or Phenobarbital) increase the synthesis of CYP enzymes. This speeds up the breakdown of other drugs metabolized by those enzymes, lowering their plasma levels and reducing their effectiveness.
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