Grapefruit juice is known to inhibit which specific CYP enzyme, leading to increased plasma levels of drugs like Statins and Felodipine?
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Correct answer: CYP3A4
Grapefruit juice contains furanocoumarins that irreversibly inhibit CYP3A4 in the intestinal wall. This reduces the first-pass metabolism of many drugs, causing a significant increase in their bioavailability and risk of toxicity.
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