Which route of administration provides 100% bioavailability by definition?
Show answer and explanation
Correct answer: Intravenous (IV)
Intravenous administration places the drug directly into the systemic venous system, bypassing all absorption barriers and first-pass metabolism. Thus, the entire dose reaches the circulation ($F = 1.0$).
Keep practicing
More Drug Absorption questions
- Which transport mechanism is characterized by moving a drug against its concentration gradient and requires the expenditure of cellular ene…
- The Henderson-Hasselbalch equation is clinically useful for predicting which aspect of drug absorption?
- What is the primary site of absorption for most orally administered drugs due to its extensive surface area and high vascularity?
- Which of the following describes 'First-Pass Metabolism'?
- A drug with a high 'Bioavailability' (F value) of 0.9 suggests that:
- How does the ionization of a weak acid drug (e.g., Aspirin) change in an alkaline environment like the small intestine?