The Henderson-Hasselbalch equation is clinically useful for predicting which aspect of drug absorption?
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Correct answer: The ratio of ionized to unionized drug at a specific pH
This equation relates the pKa of a drug and the pH of the medium to the degree of ionization. Because only unionized (lipid-soluble) molecules cross membranes easily, it helps determine the site and extent of absorption.
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More Drug Absorption questions
- What is the primary site of absorption for most orally administered drugs due to its extensive surface area and high vascularity?
- Which of the following describes 'First-Pass Metabolism'?
- A drug with a high 'Bioavailability' (F value) of 0.9 suggests that:
- How does the ionization of a weak acid drug (e.g., Aspirin) change in an alkaline environment like the small intestine?
- Which factor is most likely to delay the absorption of a drug that is primarily absorbed in the upper small intestine?
- Which route of administration is subject to the highest degree of first-pass metabolism?