Why is there a potential drug interaction between Omeprazole and the antiplatelet drug Clopidogrel?
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Correct answer: Omeprazole inhibits CYP2C19, preventing the activation of Clopidogrel
Clopidogrel is a prodrug that must be activated by the enzyme CYP2C19. Omeprazole inhibits this enzyme, which may reduce the antiplatelet efficacy of clopidogrel and increase the risk of cardiovascular events.
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