Monoclonal Antibodies · Pharmacology

Denosumab mimics the action of osteoprotegerin (OPG) by binding to which target?

  1. RANKL (Receptor Activator of Nuclear Factor kappa-B Ligand)
  2. Calcium-sensing receptor
  3. Calcitonin receptor
  4. PTH receptor
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Correct answer: RANKL (Receptor Activator of Nuclear Factor kappa-B Ligand)

Denosumab binds to RANKL, preventing it from activating the RANK receptor on osteoclast precursors. This inhibits osteoclast formation and function, thereby decreasing bone resorption in conditions like osteoporosis.

Difficulty: Medium Question 8 of 20

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