Eculizumab is used in the treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) by targeting which component?
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Correct answer: Complement protein C5
Eculizumab binds to the C5 complement protein, preventing its cleavage into C5a and C5b. This inhibits the formation of the Membrane Attack Complex (MAC), which prevents the intravascular hemolysis characteristic of PNH.
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