Dexmedetomidine provides sedation and analgesia without significant respiratory depression. What is its mechanism of action?
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Correct answer: Alpha-2 adrenergic agonist
Dexmedetomidine acts as a highly selective alpha-2 agonist in the locus coeruleus. It produces a state of 'cooperative sedation' where the patient can be easily aroused, and unlike most other sedatives, it has minimal effect on respiratory drive.
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