Which of the following describes the primary mechanism of action of first-generation (typical) antipsychotics like Haloperidol?
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Correct answer: Antagonism of Dopamine D2 receptors
Typical antipsychotics primarily work by blocking D2 receptors in the mesolimbic pathway, which reduces positive symptoms of schizophrenia. However, their high affinity for D2 receptors in the nigrostriatal pathway is responsible for extrapyramidal side effects.
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