Second-generation (atypical) antipsychotics generally differ from first-generation agents by their high affinity for which receptor subtype?
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Correct answer: Serotonin 5-HT2A
Atypical antipsychotics are characterized by a high 5-HT2A to D2 receptor binding ratio. This serotonin antagonism is thought to improve negative symptoms and reduce the incidence of extrapyramidal side effects.
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