Quetiapine is frequently used at low doses off-label for insomnia. This effect is primarily due to its antagonism of which receptor?
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Correct answer: H1 histamine receptor
Quetiapine has a very high affinity for H1 receptors. At low doses, the sedative effect of histamine blockade predominates, whereas higher doses are required to achieve the D2 blockade necessary for antipsychotic effects.
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