Antiplatelet Drugs · Pharmacology

What is the rationale for using 'Dual Antiplatelet Therapy' (DAPT) in patients following coronary stent placement?

  1. To increase the half-life of Aspirin
  2. To synergistically inhibit platelet activation through two pathways
  3. To prevent the renal tubular secretion and excretion of Clopidogrel
  4. To stimulate the production of prostacyclin (PGI2)
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Correct answer: To synergistically inhibit platelet activation through two pathways

DAPT, typically involving Aspirin and a P2Y12 inhibitor, targets both the Thromboxane A2 and ADP pathways. This combination provides superior prevention of stent thrombosis compared to using either agent alone.

Difficulty: Medium Question 9 of 20

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