Organophosphate Toxicity · Pharmacology

Aging in organophosphate poisoning refers to:

  1. Progressive liver damage
  2. Permanent binding of organophosphate to acetylcholinesterase
  3. Gradual metabolic breakdown and elimination of the pralidoxime antidote
  4. Onset of delayed neuropathy
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Correct answer: Permanent binding of organophosphate to acetylcholinesterase

Aging is the process by which the organophosphate-enzyme complex becomes permanently bound, making reactivation by pralidoxime ineffective.

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