Cholinergic Antagonists · Pharmacology

Which of the following is a quaternary ammonium compound used to reduce salivary and respiratory secretions preoperatively?

  1. Scopolamine
  2. Glycopyrrolate
  3. Atropine
  4. Trihexyphenidyl
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Correct answer: Glycopyrrolate

Glycopyrrolate is a quaternary muscarinic antagonist that does not cross the blood-brain barrier. It is preferred over atropine in some surgical settings because it has a longer duration of action and fewer CNS effects.

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