Which of the following drugs is a selective Alpha-2 agonist often used centrally to treat hypertension by decreasing sympathetic outflow?
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Correct answer: Clonidine
Clonidine stimulates Alpha-2 receptors in the medulla of the brain. This activation inhibits the release of norepinephrine from presynaptic terminals, reducing overall sympathetic drive to the heart and vasculature.
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