Which gene fusion is characteristic of acute promyelocytic leukemia?
Show answer and explanation
Correct answer: PML-RARA
The PML-RARA fusion gene results from t(15;17) and is characteristic of acute promyelocytic leukemia. It disrupts normal differentiation of myeloid cells.
Keep practicing
More Molecular Pathology of Cancer questions
- Loss of E-cadherin function contributes to cancer progression by:
- Which gene is commonly mutated in melanoma and leads to MAPK pathway activation?
- Epigenetic silencing of tumor suppressor genes commonly occurs through:
- Which hallmark of cancer is associated with VEGF overexpression?
- Which inherited mutation increases the risk of breast and ovarian cancer?
- Loss of PTEN function primarily results in: