What is the primary mode of transmission for the major systemic dimorphic fungi (e.g., Histoplasma, Coccidioides)?
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Correct answer: Inhalation of airborne spores
These fungi exist as molds in the soil and produce infectious spores (conidia/arthroconidia). When these spores are inhaled, the body's temperature triggers their transition into the pathogenic yeast or spherule phase.
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