Reversible and Irreversible Cell Injury · Pathology

Which of the following is the earliest light microscopic change seen in cells suffering from reversible hypoxic injury?

  1. Nuclear karyorrhexis
  2. Hydropic swelling
  3. Nuclear pyknosis
  4. Fatty vacuolar change
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Correct answer: Hydropic swelling

Hydropic swelling, or cloudy swelling, is the first manifestation of almost all forms of injury to cells. it results from the failure of energy-dependent membrane pumps, leading to an inability to maintain ionic and fluid homeostasis.

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