Diabetes Mellitus · Pathology

The 'polyphagia' seen in uncontrolled diabetes is caused by:

  1. Excess circulating leptin suppressing hunger
  2. Glucosuria causing rebound hunger signals
  3. Satiety center deprived of adequate glucose
  4. Gastrin hypersecretion stimulating appetite
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Correct answer: Satiety center deprived of adequate glucose

In the absence of insulin (or insulin action), the hypothalamic satiety center cannot take up glucose. This leads to a perceived 'starvation' state by the brain, despite the presence of high blood glucose levels.

Difficulty: Medium Question 14 of 20

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