Skin Biopsy Interpretation · Pathology

Which histologic pattern is most consistent with erythema multiforme?

  1. Lichenoid interface dermatitis with necrotic keratinocytes
  2. Keratin pearls
  3. Pagetoid melanocyte spread
  4. Horn cyst formation
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Correct answer: Lichenoid interface dermatitis with necrotic keratinocytes

Erythema multiforme shows interface dermatitis with necrotic keratinocytes and a perivascular lymphocytic infiltrate. It is often triggered by infections such as HSV.

Difficulty: Medium Question 15 of 20

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