Which of the following describes 'Spongiosis' in the context of acute eczematous dermatitis?
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Correct answer: Intercellular edema of the epidermis separating keratinocytes
Spongiosis is the defining feature of eczematous (dermatitic) reactions. Edema fluid collects between epidermal cells, stretching the desmosomes and giving the epidermis a sponge-like appearance.
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