A skin biopsy of a 'targetoid' lesion shows vacuolar change and necrotic keratinocytes. Which clinical association is most common for this pathology?
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Correct answer: Herpes simplex virus infection
Targetoid lesions are the hallmark of Erythema Multiforme (EM). EM is most commonly triggered by infections, particularly Herpes Simplex Virus (HSV) and Mycoplasma pneumoniae.
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