In the Salt-Split Skin technique, the autoantibodies in Bullous Pemphigoid bind to which side of the split?
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Correct answer: The epidermal roof
When skin is split through the lamina lucida using 1M NaCl, the BP180 and BP230 antigens remain with the basal keratinocytes. Therefore, the IgG in Bullous Pemphigoid localizes to the roof of the split.
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