Hailey-Hailey disease (Familial Benign Pemphigus) is caused by a defect in which of the following?
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Correct answer: ATP2C1 calcium pump
Hailey-Hailey is a genetic disorder, not autoimmune. A mutation in the ATP2C1 gene disrupts calcium signaling, leading to widespread acantholysis that looks like a 'dilapidated brick wall' histologically.
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