Pap Smear · Pathology

Which of the following is a cytological feature of Endocervical Adenocarcinoma in situ (AIS)?

  1. Isolated large keratinized squamous cells
  2. Columnar clusters with 'feathering' and crowding
  3. Single elongated cells with 'tadpole' morphology
  4. Small blue cells with 'salt and pepper' chromatin
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Correct answer: Columnar clusters with 'feathering' and crowding

AIS is the precursor to invasive endocervical adenocarcinoma. Cytologically, it appears as hyperchromatic crowded groups of columnar cells that often exhibit 'feathering' (nuclei protruding from the edges of the cluster).

Difficulty: Medium Question 17 of 20

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