Pap Smear · Pathology

In invasive squamous cell carcinoma of the cervix, which cytological feature is frequently seen that is absent in HSIL?

  1. Marked nuclear enlargement
  2. Nuclear hyperchromasia
  3. Background tumor diathesis
  4. High nuclear-to-cytoplasmic ratio
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Correct answer: Background tumor diathesis

A 'tumor diathesis'—consisting of granular necrotic debris and hemolyzed blood in the background—is a hallmark of invasive cancer. This reflects the tissue breakdown and bleeding associated with the tumor invading the stroma.

Difficulty: Medium Question 20 of 20

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